Bile reflux and bile acids in the progression of gastric intestinal metaplasia
Abstract.Gastric intestinal metaplasia (GIM) is a precancerous lesion of gastric cancer (GC) and is considered an irreversible point of progression for GC.Helicobacter pylori infection can cause GIM, but its eradication still does not reverse the process.Bile reflux is Boombox also a pathogenic factor in GIM and can continuously irritate the gastri